Journal of Oral Tissue Engineering

Effects of Test Periodontal Dressing Materials on Tubulous Structure Formation In Vitro

Koichi IMAI1, Akira AWAYA2, Akihiro UEDA1 and Masaaki NAKAMURA1

1Department of Biomaterials, Osaka Dental University
8-1, Kuzuhahanazono-cho, Hirakata-shi, Osaka 573-1121,Japan
2Japan Science and Technology Agency
2-20-5, Akebonomachi, Tachikawa-shi,Tokyo 190-0012, Japan

Original Paper:J Oral Tissue Engin 2004;1(1): 50-58

Full Text. DOI

We added two synthetic pyrimidine compounds to periodontal dressing materials and examined the increase in the area ratio of the tubule-like structure in vitro, in order to evaluate the effects on angiogenesis. Also, we examined the change in cell viability by adding these compounds. Both tests have shown that the level at which the formation of the tubule-like structure is facilitated is about 0.1 mM for both additives, and that at this level there were almost no effects on cell viability. Although the applicability of test periodontal dressing materials cannot be determined based solely on the results of this in vitro study, the application of these compounds to dentistry appears promising.
Key words: Key words: periodontal dressing material, tubule-like structure, MS-818, MS-430