Journal of Oral Tissue Engineering

ORIGINAL ARTICLE
Effect of Density of Hydroxyapatite Fiber Material on Bone Regeneration in Vertical Bone Augmentation Model

Masaki FUJII1, Makoto SHIOTA1, Kanako NORITAKE2, Kazuhiro KON1, Hitoshi SATO3 and Shohei KASUGAI1
1Oral Implantology and Regenerative Dental Medicine, Graduate school,
2Oral Diagnosis and General Dentistry,
3Oral and Maxillofacial Surgery,
Tokyo Medical and Dental University, Tokyo, Japan


J Oral Tissue Engin 2013;10(3):115-122

SYNOPSIS
The purpose of this study was to compare the effects of different densities of biodegradable hydroxyapatite fiber (HAf) material on vertical bone augmentation. Ten male Japanese white rabbits were used. Polytetrafluoroethylene chambers, which were filled with different HAf densities(termed ‘low’, ‘intermediate’, ‘high’ or ‘empty’), were fixed to the calvarial bone. After 12weeks, animals were euthanized. Specimens were radiologically analyzed with micro-computed tomography and histologically examined. In the intermediate-density group the new bone volume was the highest. The present results suggest the potentiality of this material as bone substitute and the importance of material density in its application.

Key words: hydroxyapatite, fiber, density, bone