Journal of Oral Tissue Engineering

Utility of Prototype Porous Titanium as a Bone Regeneration Scaffold

Teruo HIGA1, Atsuko UENO2, Tatsuhide HAYASHI3, Akiko ABE2, Yuzo OHNO4, Tatsushi KAWAI3 and Kenichi KURITA1
1Department of Oral and Maxillofacial Surgery,
2Department of Gerodontology,
3Department of Dental Material Science,
4Department of Periodontology School of Dentistry,
Aichi Gakuin University, Nagoya, Japan

J Oral Tissue Engin 2013;10(3):163-171

This study examined titanium onto which bioactive factors were adsorbed, with the objective of developing a scaffold with many pores that could be expected to promote cell infiltration. Titanium powder was mixed with ammonium hydrogen carbonate as a binder in a 5:5 ratio by weight, and a method based on the powder metallurgy method was used to construct a prototype scaffold. Bone morphogenetic protein (BMP) was adsorbed onto the prototype scaffold, and its osteoinductive potential was evaluated. The results showed that the prototype scaffold possessed pores capable of infiltration by cells, and that sufficient osteoinduction was possible without suppressing the activity of BMP.

Key words: Bone morphogenetic protein (BMP), pores titanium, Soft X-ray evaluation, Microfocus X-ray computed tomography (CT) analysis, Electron probe micro analyzer (EPMA) surface analysis