!15-3-8e.html> Comparison of Bone Regeneration Following Autogenous Bone Grafting and Dentin Transplantation
Journal of Oral Tissue Engineering



ORIGINAL ARTICLE
Comparison of Bone Regeneration Following Autogenous Bone Grafting and Dentin Transplantation

Kenichirou YASUI1, Yoshiyuki ARIMA1, Yuzi NAKAYAMA1, Eiki HARA1, Masayasu TATSUMURA1, Peiqi LI2, Eiko AZUMI1, Yukiko HOSOHAMA1, Kaoru INAMI1, Aki NISHIAURA1, Yoshiya HASHIMOTO3, Yoshitomo HONDA4, Shunsuke BABA2, and Naoyuki MATSUMOTO1

1Department of Orthodontics, 2Department of Oral Implantology,
3Department of Biomaterials, 4Institute of Dental Research,
Osaka Dental University, Osaka, Japan


J Oral Tissue Engin 2018; 15(3): 177-185.

SYNOPSIS
This study compared bone regeneration ability following non-demineralized dentin granule transplantation and autogenous bone grafting. A critical-sized bone defect was created at the center of the calvaria in rats, and autologous bone and dentin were transplanted. All specimens were evaluated microradiographically and histologically. Computed tomography (CT) analysis revealed no difference in the amount of hard tissue between the dentin-transplanted group and the autologous bone-grafted group 8 weeks after surgery. Tissue analysis revealed that the defect was almost entirely replaced with new bone in the autogastric bone-grafted group 8 weeks after surgery. About half of the dentin granules remained in the dentin-transplanted group, and the rest were replaced with autologous bone. These results suggest that dentin was slowly replaced by new bone while securing the space at the transplantation site, even after a long period of transplantation.

Key words: bone tissue engineering, autologous bone graft, dentin graft, CT analysis, rat calvarial defect



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