SYNOPSIS
Periodontitis is common in adults and cardiovascular diseases are the most common cause of adult death in the world. However opening of the infarct-related coronary artery is a valued therapeutic goal in acute myocardial infarction, cardiomyocytes continue to die during reperfusion. Acute oxidative stress induced by ischemia -reperfusion causes serious damage to tissue. The purpose of our study was to investigate that hydrogen (H₂) gas has potential as an antioxidant in preventive and therapeutic applications. We first determined the dose at which cytotoxicity develops in a period of 1 h upon antimycin A (AA) exposure in H9c2 cells. AA (0-500 µM) exhibited cytotoxicity in a concentration-dependent manner. A maximum reduction was 76.5 ± 4 of the control group (at 500 µmM of AA). AA-induced cytotoxicity in H9c2 cells were improved by H₂ gas. These results suggested the protective effects H₂ gas against AA- induced injury in H9c2 cells.

Key words: hydrogen gas, antimycin A, oxidative stress, H9c2

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All documents in this paper

J-Stage https://www.jstage.jst.go.jp/article/jarde/16/1/16_16_21/_article/-char/en

DOI https://doi.org/10.11223/jarde.16.21

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