This study was designed to examine the effects of transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2) on bone formation using a bioabsorbable scaffold at palatal subperiosteal sites in rats.
Alginate gel containing TGF-β1 (0.0 or 0.1µg / µL) and BMP-2 (0.0 or 0.1µg / µL) were used for implantation, and experimental sites were divided into four groups according to the cytokines contained in the scaffold: TGF group (TGF-β1), BMP group (BMP-2), TGF+BMP group (TGF-β1 and BMP-2) and Control group.
Four weeks after implantation, thickness of new bone (TNB) was significantly higher in TGF group and BMP group than in Control group (P<0.05). There was no significant difference in TNB between TGF group and BMP group (P>0.05).
On the other hand, TNB was significantly higher in TGF+BMP group than in TGF group and BMP group (P<0.05).
These results suggest that TGF-β1 and BMP-2 contained in alginate gel have interactive effects on bone formation in the case of palatal subperiosteal sites.
Key words: TGF-β1, BMP-2, bone formation
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