Journal of Oral Tissue Engineering

Effects of BMP-2 on Bone Response using Gelatin Hydrogel in Estrogen-deficient Rats

Tsutomu SUGAYA2, Yasushi SHIMADA3, Naoko OHARA1,
and Masahiro YOSHIYAMA1

1 Department of Operative Dentistry, Okayama University Graduate School of Medicine,
Dentistry and Pharmaceutical Science, Okayama, Japan
2 Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
3 Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences,
Tokyo Medicinal and Dental University, Tokyo, Japan

J Oral Tissue Engin 2022; 20(2): 41-46.

This study was designed to examine the effects of bone morphogenetic protein-2 (BMP-2) on bone response at palatal site using gelatin hydrogel in ovariectomized (OVX group) and normal female rats (Normal group). The experimental sites in both groups were divided into two sites: implantation with gelatin hydrogel containing BMP-2 (BMP site) and gelatin hydrogel only (Gel site). Four weeks after implantation, new bone formation was observed at every site and the new bone volume (NBV) of the BMP site was significantly greater than that of the Gel site of both groups (p<0.05). The NBV of every site in Normal group was significantly greater than that of the same experimental site in OVX group (p<0.05).
These results suggest that the gelatin hydrogel containing BMP-2 induce new bone formation at palatal site even in estrogen-deficient rats, whereas the new bone volume is less than in normal rats.

Key words: BMP-2, bone formation, osteoporosis

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