Journal of Oral Tissue Engineering

Observation of Bone Formation at Peri-implant Tissue with Microcomputed Tomography

Tetsunari NISHIKAWA1, Kazuya MASUNO1, Ayako KAWANAKA1, Kazuya TOMINAGA1, Tomoaki HIDA1, Yasuhiro TAJIME2, Masayuki TSUNOKUMA2, Kenji KAKUDO2, Kazuyo YAMAMOTO3 and Akio TANAKA1

1Department of Oral Pathology, Osaka Dental University
2The Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
3Department of Operative Dentistry, Osaka Dental University

J Oral Tissue Engin 2005;3(2): 97-104

Full Text. DOI

In the present study we attempted to observe the 3-dimensional morphology during the process of bone calcification at peri-implant tissue, with the use of microcomputed tomography (micro-CT). Six titanium implants were placed in the maxillary bone of 3 beagle bogs. At 4, 8 and 12 weeks after implantation, the dogs were sacrificed and the interface between new bone formation and implants in undecalcified blocks was investigated using micro-CT.
At 4 weeks after implantation, there was little bone formation between host bone and the implant. At 8 weeks after implantation, new bone formation was seen as an extension of calcification from host bone. At 12 weeks after implantation, there were increases of bone volume at the peri-implant tissue. Micro-CT could be used to observe the necked eye figures and quantify the bone remodeling system at peri-implant tissue. This technique has the advantage of enabling 3-dimensional analysis of the interface between the modeling bone and the titanium implant following surgery. In addition, the micro-CT technique allowed examination at higher magnification in this area.

Key words:Microcomputed tomography, Implant, Titanium, Histomorphometry