Journal of Oral Tissue Engineering

ORIGINAL ARTICLE
 Study on Bone Formation Induced by Recombinant Human BMP-2 at Palatal Sites in Adult Rats

 Kozo YAMAJI, Toshiyuki ITOTA, Shunji IZAWA, Yoshihiro NISHITANI and Masahiro YOSHIYAMA

 Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
J Oral Tissue Engin 2006;4(1): 37-42
Full Text. DOI https://doi.org/10.11223/jarde.4.37
SYNOPSIS
This study was designed to examine the effects of bone formation induced by recombinant human BMP-2 (rhBMP-2), which was implanted together with a poly-lactate-polyglycolate-copolymer/gelatine sponge (PGS) at palatal sites in 30-week-old male Wister rats. The rats were divided into four groups according to the dose of rhBMP-2: 0µg, 4µg, 8µg and 16µg. New bone formation was observed in every group, and new bone was continuous with the original bone at 6 weeks after implantation. Thickness of new bone (TNB) increased as the dose increased from 0µg to 8µg, reached the maximal level at 8µg. In contrast, TNB decreased significantly as the dose increased from 8µg to 16µg.
The results of this study indicate that new bone formation varies according to the dose of rhBMP-2 at palatal sites in adult rats.

Key words: bone formation, rhBMP-2, adult rat