Journal of Oral Tissue Engineering

Bone Formation Induced by Recombinant Human BMP-2 Combined with Bioabsorbable Material at Subperiosteal Sites

Kozo YAMAJI, Yoshihiro NISHITANI, Shunji IZAWA, Yasuo SHINNO, Masanori OMAE and Masahiro YOSHIYAMA

Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JAPAN

J Oral Tissue Engin 2006;4(2): 101-105

Full Text. DOI

The purpose of this study was to evaluate the effect of bone formation induced by recombinant human BMP-2 (rhBMP-2) combined with bioabsorbable material Kurabio®AG (AG) at palatal subperiosteal sites in Wistar rats. AG was freeze-dried alginated gel dressing.
Experimental sites were divided into three groups according to the implans : BMP group (rhBMP-2 combined with AG), AG group (AG alone) and Control group.
In every group, infected region or atypical cell proliferation was not observed, and new bone formation was observed at 6 weeks after implantation. Thickness of new bone (TNB) of BMP group was significantly higher than that of AG and Control groups. There was no significant difference in TNB between AG and Control groups.
These results suggest that rhBMP-2 combined with AG have the ability to promote bone formation, although AG alone do not have any effect on bone for-mation.

Key words:bone formation, rhBMP-2, bioabsorbable material