Journal of Oral Tissue Engineering

REVIEW
Molecular Basis of Bone Regeneration and Its Application to Development of Cell-mediated Therapy of Bone Repair

Akira YAMAGUCHI

Division of Oral Pathology, Tokyo Medical and Dental University, Japan


J Oral Tissue Engin 2007;4(3): 117-120

Full Text. DOI https://doi.org/10.11223/jarde.4.117

SYNOPSIS
Bone regeneration is accompanied by a cascade of events. Migration and prolif-eration of osteogenic cells occurred at the early stage of bone regeneration, and these osteogenic cells are involved in the synthesis of the bone matrix and its mineralization depending on their maturation stages. The remodeling of fracture callus is a crucial event that restores mechanical integrity and integrates the newly formed bone into the preexisting skeletal structure. Various molecules are involved in these processes to achieve complete bone healing, but the molecular mecha-nism underlying these processes has not been fully understood. To develop biol-ogy-based regenerative medicine/dentistry, we conduct BONE REGENERATION PROJECT by investigating molecular mechanism of osteoblast differentiation and bone regeneration. I will present some results from this project.

Key words: Bone regeneration, BMP, Notch, Osteoblast