SYNOPSIS
In the present study, we aimed to investigate the bone adaptability of commercially available biodegradable materials. Four natural polymer biodegradable materials, Avitene, Sponzel, Terdermis, Koken Tissue Guide and one synthetic polymer material, GC membrane, were immersed into Hanks' balanced salt solution (HBSS) without organic species with pH=7.4 for 14 days. HBSS was used as a simulated body fluid (SBF), and SBF immersion experiment was performed as preliminary experiment of in vivo animal experiment. Avitene and Sponzel have been dissolved in HBSS. Apatite formation was detected on Terdermis, Koken Tissue Guide and GC membrane. Micro X-ray diffraction measurement revealed the formation of hydroxyapatite on three biodegradable materials after HBSS immersion. We can make clear the biocompatibility of different biodegradable materials using simple HBSS immersion experiment.

Key words: biomaterials, hydroxyapatite, biocompatibility, simulated body fluid