Journal of Oral Tissue Engineering

ORIGINAL ARTICLE
 The Effects of Collagen Hydrogel Implantation in Buccal Dehiscence Defects in Beagles

 Hirofumi MIYAJI1, Tsutomu SUGAYA1, Katsuya KATO2, Naoto KAWAMURA1 and Masamitsu KAWANAMI1

1 Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
2 Shiba Dental Office, Tokyo, Japan

J Oral Tissue Engin 2007;5(2): 87-95
Full Text. DOI https://doi.org/10.11223/jarde.5.87
SYNOPSIS
Type I collagen hydrogel treated by an ascorbate-copper ion crosslinking system is highly biocompatible and highly degradable in the body. The purpose of this study was to examine the effect of collagen hydrogel on periodontal wound healing in beagles. Sixty-four periodontal dehiscence type defects were created on the buccal roots of four beagles. Subsequently, collagen hydrogel was implanted in each defect in the experimental group and sutured, and, in the control group, the defect was sutured without any application of collagen hydrogel. The percentage of the length of new bone and new cementum in the experimental group was significantly greater than that in the control group at weeks 4 (p<0.01) and 8 (p<0.05). Significantly more junctional epithelium was observed in the control group than in the experimental group at weeks 2 (p<0.01) and 4 (p<0.05). These findings thus indicate that periodontal regeneration was stimulated by collagen hydrogel implantation in beagles.

Key words: collagen hydrogel, periodontal regeneration, scafforld, barrier