Journal of Oral Tissue Engineering

Effect of Hydroxyapatite Fiber Material on Rat Incisor Socket Healing

Tetsu MACHIDA1, Myat NYAN1, Kazuhiro KON1, Katsuichiro MARUO1, Hitoshi SATO2 and Shohei KASUGAI1, 3
1Oral Implantology and Regenerative Dental Medicine, Graduate school,
2Oral and Maxillofacial Surgery, 3Global Center of Excellence (GCOE) Program;
International Research Center for molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University , Tokyo , Japan

J Oral Tissue Engin 2010;7(3): 153-162

Full Text. DOI

The purpose of the present study was to examine effects of hydroxyapatite fiber material (HF) on the socket healing after tooth extraction. Right mandibular incisors of 12-week-old male Wistar rats were extracted and the sockets were filled with 60mg HF or left empty. The animals were injected with fluorescence dyes for histomorphometrical analysis and they were sacrificed at 0, 2, 4, 8 and 12 weeks after tooth extraction. Socket healing was radiologically evaluated with micro CT and dual energy x-ray absorptiometer and histologically examined. Although there was no significant difference in mineral apposition rate, the bone volume and bone mineral content of the experimental group were higher than those of the control group at all time points (p<0.05). The amount of HF in the socket gradually decreased from 4 weeks to 8 weeks, and disappeared almost completely at 12 weeks. HF not only allowed but also promoted the bone healing of the socket and it could be applicable for alveolar bone preservation after tooth extraction.

Key words: hydroxyapatite fiber material, alveolar bone regeneration, dental implant